MODIFICATION OF [18F]FDG BY THE FORMATION OF A HYDRAZONE BOND

Purpose: The [18F]-fluorodeoxyglucose ([18F]-FDG) is known to be one of the most used radio-pharmaceuticals for positron emission tomography. [18F]-FDG allows assessment glycolytic activity, which more enhanced in tumor cells than normal cells. It also heart and neurological diseases. aim our work follow possibility modifying develop an indirect radiofluorination procedure applicable under standard clinical conditions. Material/Methods: In clinic nuclear medicine at University Hospital Sta. Marina-Varna, routine purposes, produced by nucleophilic method fluorination, using mannose triflate as a precursor. addition being universal radiopharmaceutical, may involved prosthetic group biorthogonal reactions. [18F]-glycosylation oxime or hydrazone formation chemoselective sensitive molecules. process can improve pharmacokinetics stability labeled compounds blood. Results: We developed fluorine-deoxyglucose forming bond with bifunctional tetrazine {3-[4-(6-phenyl-[1,2,4,5]-tetrazine-3-yl)-phenoxy]-propyl}-hydrazine) (Tz). progress product obtained were monitored radio TLC. radiolabeled will future click reactions trans-cyclooctene physiological